Target:PDK2
Fields:Diabetic cardiomyopathy
Gene Name:PDK2
Protein Name:[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 mitochondrial
Human Gene Id:5164
Human Swiss Prot No:Q15119
Mouse Gene Id:18604
Mouse Swiss Prot No:Q9JK42
Rat Gene Id:81530
Rat Swiss Prot No:Q64536
Immunogen:The antiserum was produced against synthesized peptide derived from human PDK2. AA range:260-309
Specificity:PDK2 Polyclonal Antibody detects endogenous levels of PDK2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PDK2;PDHK2;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial;Pyruvate dehydrogenase kinase isoform 2
Observed Band(KD):46kD
Background: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Function:catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.,
Subcellular Location:Mitochondrion matrix.
Expression:Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.