Target：RHEB

Fields：Phospholipase D signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Cellular senescence;Thermogenesis;Insulin signaling pathway;Thyroid hormone signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Herpes simplex virus 1 infection;Choline metabolism in cancer

Gene Name：RHEB RHEB2

Protein Name：RHEB

Human Gene Id：6009

Human Swiss Prot No：Q15382

Mouse Gene Id：19744

Mouse Swiss Prot No：Q921J2

Rat Swiss Prot No：Q62639

Immunogen：Synthetic Peptide of RHEB

Specificity：This antibody detects endogenous levels of RHEB Polyclonal Antibody at Human;Mouse;Rat;Predicted:Cow, It doesn't reacte with total protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Ras homolog enriched in brain

Observed Band(KD)：20kD

Background： This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008],

Function：function:Not known; binds GTP and exhibits intrinsic GTPase activity.,similarity:Belongs to the small GTPase superfamily. Rheb family.,tissue specificity:Ubiquitous. Highest levels observed in skeletal and cardiac muscle.,

Subcellular Location：Endomembrane system ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .

Expression：Ubiquitous. Highest levels observed in skeletal and cardiac muscle.