Target：Fucokinase

Fields：Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of nucleotide sugars

Gene Name：FUK

Protein Name：L-fucose kinase

Human Gene Id：197258

Human Swiss Prot No：Q8N0W3

Immunogen：The antiserum was produced against synthesized peptide derived from human FUK. AA range:11-60

Specificity：Fucokinase Polyclonal Antibody detects endogenous levels of Fucokinase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FUK;L-fucose kinase;Fucokinase

Observed Band(KD)：110kD

Background：fucokinase(FUK) Homo sapiens The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.,function:Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.,similarity:Belongs to the GHMP kinase family.,

Subcellular Location：cytoplasm,cytosol,

Expression：Expressed in fibroblasts.