Target：AASD-PPT

Fields：Pantothenate and CoA biosynthesis;Metabolic pathways

Gene Name：AASDHPPT

Protein Name：L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Human Gene Id：60496

Human Swiss Prot No：Q9NRN7

Mouse Gene Id：67618

Mouse Swiss Prot No：Q9CQF6

Rat Gene Id：300328

Rat Swiss Prot No：B2RYJ4

Immunogen：The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60

Specificity：AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AASDHPPT;CGI-80;HAH-P;HSPC223;x0005;L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase;4'-phosphopantetheinyl transferase;Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase;AASD-PPT;

Observed Band(KD)：36kD

Background： The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],

Function：catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.,

Subcellular Location：Cytoplasm, cytosol .

Expression：Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.