Target：PIGR

Fields：Intestinal immune network for IgA production

Gene Name：PIGR

Protein Name：Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]

Human Gene Id：5284

Human Swiss Prot No：P01833

Mouse Swiss Prot No：O70570

Rat Swiss Prot No：P15083

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PIGR Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：84kD

Background：polymeric immunoglobulin receptor(PIGR) Homo sapiens This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009],

Function：function:This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.,PTM:N-glycosylation is not necessary for Ig binding.,similarity:Contains 5 Ig-like V-type (immunoglobulin-like) domains.,

Subcellular Location：[Polymeric immunoglobulin receptor]: Cell membrane ; Single-pass type I membrane protein .; [Secretory component]: Secreted .

Expression： Bile,Liver,Milk,Plasma,Saliva,Small intestine,