Target：pICln

Gene Name：CLNS1A

Protein Name：Methylosome subunit pICln

Human Gene Id：1207

Human Swiss Prot No：P54105

Mouse Swiss Prot No：Q61189

Immunogen：The antiserum was produced against synthesized peptide derived from human CLNS1A. AA range:184-233

Specificity：pICln Polyclonal Antibody detects endogenous levels of pICln protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CLNS1A;CLCI;ICLN;Methylosome subunit pICln;Chloride channel; nucleotide sensitive 1A;Chloride conductance regulatory protein ICln;I(Cln);Chloride ion current inducer protein;ClCI;Reticulocyte pICln

Observed Band(KD)：37kD

Background： This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015],

Function：function:The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the pICln family.,subcellular location:A small fraction is also associated with the cytoskeleton.,subunit:Homooligomer. Component of the methylosome, a 20S complex containing SKB1. Interacts with Sm proteins.,

Subcellular Location：Cytoplasm, cytosol . Nucleus . Cytoplasm, cytoskeleton . A small fraction is also associated with the cytoskeleton (PubMed:18984161).

Expression： Cervix carcinoma,Colon cancer,Colon carcinoma,Embryonic kid