Target：PRKRA
Gene Name：PRKRA PACT RAX HSD-14 HSD14
Protein Name：Interferon-inducible double stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Prote
Human Gene Id：8575
Human Swiss Prot No：O75569
Mouse Swiss Prot No：Q9WTX2
Rat Swiss Prot No：Q4V8C7
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：PRKRA Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：34kD
Background： This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008],
Function：disease:Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.,function:Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (By similarity). Activates EIF2AK2 in absence of double stranded RNA (dsRNA).,PTM:Phosphorylated on serine.,similarity:Contains 3 DRBM (double-stranded RNA-binding) domains.,subunit:Heterodimer. Interacts with EIF2AK2 through its DRBM domains. Also able to interact with dsRNA.,
Subcellular Location：Cytoplasm, perinuclear region. Cytoplasm.
Expression： Brain,Epithelium,Placenta,Testis,
