Target：PRIC285

Gene Name：PRIC285

Protein Name：Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein

Human Gene Id：85441

Human Swiss Prot No：Q9BYK8

Immunogen：The antiserum was produced against synthesized peptide derived from human PRIC285. AA range:1909-1958

Specificity：PRIC285 Polyclonal Antibody detects endogenous levels of PRIC285 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PRIC285;KIAA1769;Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein;ATP-dependent helicase PRIC285;PPAR-alpha-interacting complex protein 285;PPAR-gamma DNA-binding domain-interacting protein 1;PDIP1;PP

Observed Band(KD)：300kD

Background： The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：caution:PubMed:12189208 experiments have been carried out partly in rat and partly in human.,domain:Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.,function:Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.,similarity:Belongs to the DNA2/NAM7 helicase family.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Interacts with PPARA, ESR1, THRB and RXRA. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC). Also interacts with the DNA-binding domain of PPARG.,tissue specificity:Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.,

Subcellular Location：Nucleus .

Expression：Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.