Target：PPM1B

Fields：MAPK signaling pathway

Gene Name：PPM1B PP2CB

Protein Name：Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)

Human Gene Id：5495

Human Swiss Prot No：O75688

Mouse Swiss Prot No：P36993

Rat Swiss Prot No：P35815

Immunogen：Synthesized peptide derived from human protein . at AA range: 310-390

Specificity：PPM1B Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：52kD

Background： The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist,catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.,similarity:Belongs to the PP2C family.,subunit:Monomer.,tissue specificity:Highly expressed in heart and skeletal muscle.,

Subcellular Location：Cytoplasm, cytosol . Membrane ; Lipid-anchor . Weakly associates at the membrane and N-myristoylation mediates the membrane localization. .

Expression：Highly expressed in heart and skeletal muscle.