Target:PP2Cκ
Gene Name:PPM1K
Protein Name:Protein phosphatase 1K mitochondrial
Human Gene Id:152926
Human Swiss Prot No:Q8N3J5
Mouse Swiss Prot No:Q8BXN7
Immunogen:The antiserum was produced against synthesized peptide derived from human PPM1K. AA range:205-254
Specificity:PP2Cκ Polyclonal Antibody detects endogenous levels of PP2Cκ protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PPM1K;PP2CM;Protein phosphatase 1K; mitochondrial;PP2C domain-containing protein phosphatase 1K;PP2C-like mitochondrial protein;PP2C-type mitochondrial phosphoprotein phosphatase;PTMP;Protein phosphatase 2C isoform kappa;PP2C-kappa
Observed Band(KD):45kD
Background: This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012],
Function:catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,
Subcellular Location:Mitochondrion matrix .
Expression: Amygdala,Cerebellum,Lymph node,Pancreas,Testis,