Target：PP2BC

Fields：MAPK signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Oocyte meiosis;Cellular senescence;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;C-type lectin receptor signaling pathway;Natural killer cell mediated cytotoxicity;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Oxytocin signaling pathway;Glucagon signaling pathway;Renin secretion;Alzheimer disease;Amyotrophic lateral sclerosis;Prion disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Tuberculosis;Human cytomegalovirus infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Human immunodeficiency virus 1 infection;PD-L1 expression and PD-1 checkpoint pathway in cancer;Lipid and atherosclerosis

Gene Name：PPP3CC CALNA3 CNA3

Protein Name：Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A s

Human Gene Id：5533

Human Swiss Prot No：P48454

Mouse Swiss Prot No：P48455

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PP2BC Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：56kD

Background： Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

Function：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.,tissue specificity:Testis.,

Subcellular Location：Mitochondrion . Localizes in the mitochondria in a SPATA33-dependent manner. .

Expression：Testis.