Target：PP2A-B56-δ

Fields：mRNA surveillance pathway;Sphingolipid signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;AMPK signaling pathway;Adrenergic signaling in cardiomyocytes;Dopaminergic synapse;Human papillomavirus infection

Gene Name：PPP2R5D

Protein Name：Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

Human Gene Id：5528

Human Swiss Prot No：Q14738

Immunogen：The antiserum was produced against synthesized peptide derived from human PPP2R5D. AA range:544-593

Specificity：PP2A-B56-δ Polyclonal Antibody detects endogenous levels of PP2A-B56-δ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPP2R5D;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;PP2A B subunit isoform B'-delta;PP2A B subunit isoform B56-delta;PP2A B subunit isoform PR61-delta;PP2A B subunit isoform R5-delta

Observed Band(KD)：70kD

Background： The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,induction:By retinoic acid; in neuroblastoma cell lines.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the phosphatase 2A regulatory subunit B56 family.,subcellular location:Nuclear in interphase, nuclear during mitosis.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins,

Subcellular Location：Cytoplasm. Nucleus. Nuclear in interphase, nuclear during mitosis.

Expression：Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.