Target:PXR
Gene Name:NR1I2
Protein Name:Nuclear receptor subfamily 1 group I member 2
Human Gene Id:8856
Human Swiss Prot No:O75469
Mouse Swiss Prot No:O54915
Immunogen:The antiserum was produced against synthesized peptide derived from human NR1I2. AA range:91-140
Specificity:PXR Polyclonal Antibody detects endogenous levels of PXR protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:NR1I2;PXR;Nuclear receptor subfamily 1 group I member 2;Orphan nuclear receptor PAR1;Orphan nuclear receptor PXR;Pregnane X receptor;Steroid and xenobiotic receptor;SXR
Observed Band(KD):50kD
Background: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008],
Function:function:Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.,induction:Activated by naturally occurring steroids such as pregnenolone and progesterone.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Forms a heterodimer with RXR.,tissue specificity:Expressed in liver, colon and small intestine.,
Subcellular Location:Nucleus .
Expression:Expressed in liver, colon and small intestine.