Target：PTP22

Gene Name：PTPN22

Protein Name：Tyrosine-protein phosphatase non-receptor type 22

Human Gene Id：26191

Human Swiss Prot No：Q9Y2R2

Mouse Gene Id：19260

Mouse Swiss Prot No：P29352

Immunogen：Synthesized peptide derived from the N-terminal region of human PTP22.

Specificity：PTP22 Polyclonal Antibody detects endogenous levels of PTP22 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTPN22;PTPN8;Tyrosine-protein phosphatase non-receptor type 22;Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP;Lymphoid phosphatase;LyP;PEST-domain phosphatase;PEP

Observed Band(KD)：91kD

Background： This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009],

Function：catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.,

Subcellular Location：Cytoplasm .

Expression：Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.