Target：RAB23

Gene Name：RAB23 HSPC137

Protein Name：Ras-related protein Rab-23

Human Gene Id：51715

Human Swiss Prot No：Q9ULC3

Mouse Swiss Prot No：P35288

Immunogen：Synthesized peptide derived from human protein . at AA range: 120-200

Specificity：RAB23 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：26kD

Background： This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Function：disease:Defects in RAB23 are the cause of Carpenter syndrome [MIM:201000]; also known as acrocephalopolysyndactyly type 2 (ACPS2). Carpenter syndrome is characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Inheritance is autosomal recessive.,similarity:Belongs to the small GTPase superfamily. Rab family.,

Subcellular Location：Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm . Cytoplasmic vesicle, autophagosome . Endosome membrane . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Recruited to phagosomes containing S.aureus or M.tuberculosis. .

Expression： Brain,Fetal brain,Hair follicle,Umbilical cord blood,Uterus,