Target:RASSF6
Fields:Hippo signaling pathway;Hippo signaling pathway - multiple species
Gene Name:RASSF6
Protein Name:Ras association domain-containing protein 6
Human Gene Id:166824
Human Swiss Prot No:Q6ZTQ3
Mouse Swiss Prot No:Q80UQ2
Immunogen:The antiserum was produced against synthesized peptide derived from human RASSF6. AA range:129-178
Specificity:RASSF6 Polyclonal Antibody detects endogenous levels of RASSF6 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:RASSF6;Ras association domain-containing protein 6
Observed Band(KD):45kD
Background: This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012],
Function:function:May act as a Ras effector protein.,sequence caution:Translated as Gln.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,
Expression:Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.