Target：Ran BP-17

Fields：Nucleocytoplasmic transport

Gene Name：RANBP17

Protein Name：Ran-binding protein 17

Human Gene Id：64901

Human Swiss Prot No：Q9H2T7

Mouse Gene Id：66011

Mouse Swiss Prot No：Q99NF8

Immunogen：The antiserum was produced against synthesized peptide derived from human RANBP17. AA range:145-194

Specificity：Ran BP-17 Polyclonal Antibody detects endogenous levels of Ran BP-17 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RANBP17;Ran-binding protein 17

Observed Band(KD)：125kD

Background：RAN binding protein 17(RANBP17) Homo sapiens The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002],

Function：function:May function as a nuclear transport receptor.,similarity:Belongs to the exportin family.,subunit:Binds to nucleoporins and the GTP-bound form of Ran.,tissue specificity:Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.,

Subcellular Location：Cytoplasm . Nucleus . Nucleus, nuclear pore complex .

Expression：Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.