Target:RAMP1
Fields:Vascular smooth muscle contraction
Gene Name:RAMP1
Protein Name:Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
Human Gene Id:10267
Human Swiss Prot No:O60894
Mouse Swiss Prot No:Q9WTJ5
Rat Swiss Prot No:Q9JJ74
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:RAMP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):16kD
Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided b
Function:function:Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.,similarity:Belongs to the RAMP family.,subunit:Heterodimer of CALCRL and RAMP1.,tissue specificity:Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.,
Subcellular Location:Membrane; Single-pass type I membrane protein.
Expression:Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.