Target:TEF-1
Fields:Hippo signaling pathway;Hippo signaling pathway - multiple species
Gene Name:TEAD1
Protein Name:Transcriptional enhancer factor TEF-1
Human Gene Id:7003
Human Swiss Prot No:P28347
Mouse Gene Id:21676
Mouse Swiss Prot No:P30051
Immunogen:Synthesized peptide derived from TEF-1 . at AA range: 30-110
Specificity:TEF-1 Polyclonal Antibody detects endogenous levels of TEF-1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TEAD1;TCF13;TEF1;Transcriptional enhancer factor TEF-1;NTEF-1;Protein GT-IIC;TEA domain family member 1;TEAD-1;Transcription factor 13;TCF-13
Observed Band(KD):50kD
Background: This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010],
Function:disease:Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.,function:Binds specifically and cooperatively to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.,similarity:Contains 1 TEA DNA-binding domain.,tissue specificity:Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.,
Subcellular Location:Nucleus.
Expression:Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.