Target：Thymidine Kinase

Fields：Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Nucleotide metabolism

Gene Name：TK1

Protein Name：Thymidine kinase cytosolic

Human Gene Id：7083

Human Swiss Prot No：P04183

Mouse Gene Id：21877

Mouse Swiss Prot No：P04184

Rat Gene Id：24834

Rat Swiss Prot No：P27158

Immunogen：The antiserum was produced against synthesized peptide derived from human TK. AA range:1-50

Specificity：Thymidine Kinase Polyclonal Antibody detects endogenous levels of Thymidine Kinase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TK1;Thymidine kinase; cytosolic

Observed Band(KD)：25kD

Background：catalytic activity:ATP + thymidine = ADP + thymidine 5'-phosphate.,miscellaneous:Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.,PTM:Phosphorylated on Ser-13 in mitosis.,similarity:Belongs to the thymidine kinase family.,

Function：catalytic activity:ATP + thymidine = ADP + thymidine 5'-phosphate.,miscellaneous:Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.,PTM:Phosphorylated on Ser-13 in mitosis.,similarity:Belongs to the thymidine kinase family.,

Subcellular Location：Cytoplasm.

Expression： Epithelium,Lymph,Skin,Uterus,