Target:TGF β Receptor I
Fields:MAPK signaling pathway;Cytokine-cytokine receptor interaction;FoxO signaling pathway;Endocytosis;Cellular senescence;TGF-beta signaling pathway;Apelin signaling pathway;Osteoclast differentiation;Hippo signaling pathway;Adherens junction;Th17 cell differentiation;Relaxin signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Chagas disease;Hepatitis B;Human T-cell leukemia virus 1 infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;Hepatocellular carcinoma;Gastric cancer;Diabetic cardiomyopathy
Gene Name:TGFBR1
Protein Name:TGF-beta receptor type-1
Human Gene Id:7046
Human Swiss Prot No:P36897
Mouse Gene Id:21812
Mouse Swiss Prot No:Q64729
Rat Swiss Prot No:P80204
Immunogen:The antiserum was produced against synthesized peptide derived from human TGF beta Receptor I. AA range:131-180
Specificity:TGFβ RI Polyclonal Antibody detects endogenous levels of TGFβ RI protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TGFBR1;ALK5;SKR4;TGF-beta receptor type-1;TGFR-1;Activin A receptor type II-like protein kinase of 53kD;Activin receptor-like kinase 5;ALK-5;ALK5;Serine/threonine-protein kinase receptor R4;SKR4;TGF-beta type I receptor;Transfor
Observed Band(KD):56kD
Background: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function:catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,disease:Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tort
Subcellular Location:Cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Cell surface . Membrane raft .
Expression:Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).