Target：TMEM16A

Gene Name：ANO1

Protein Name：Anoctamin-1

Human Gene Id：55107

Human Swiss Prot No：Q5XXA6

Mouse Swiss Prot No：Q8BHY3

Immunogen：The antiserum was produced against synthesized peptide derived from human TM16A. AA range:921-970

Specificity：TMEM16A Polyclonal Antibody detects endogenous levels of TMEM16A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ANO1;DOG1;ORAOV2;TAOS2;TMEM16A;Anoctamin-1;Discovered on gastrointestinal stromal tumors protein 1;Oral cancer overexpressed protein 2;Transmembrane protein 16A;Tumor-amplified and overexpressed sequence 2

Molecular Weight(Da)：114kD

Background：domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,

Function：domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. .

Expression：Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.