Target：TM4SF1

Gene Name：TM4SF1

Protein Name：Transmembrane 4 L6 family member 1

Human Gene Id：4071

Human Swiss Prot No：P30408

Mouse Gene Id：17112

Mouse Swiss Prot No：Q64302

Immunogen：The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50

Specificity：TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TM4SF1;M3S1;TAAL6;Transmembrane 4 L6 family member 1;Membrane component chromosome 3 surface marker 1;Tumor-associated antigen L6

Molecular Weight(Da)：22kD

Background： The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],

Function：similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.,

Subcellular Location：Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). .

Expression：Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.