Target：TKT

Fields：Pentose phosphate pathway;Metabolic pathways;Carbon metabolism;Biosynthesis of amino acids

Gene Name：TKT

Protein Name：Transketolase (TK) (EC 2.2.1.1)

Human Gene Id：7086

Human Swiss Prot No：P29401

Mouse Swiss Prot No：P40142

Rat Swiss Prot No：P50137

Immunogen：Synthesized peptide derived from part region of human protein AA range: 125-175

Specificity：TKT Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：68kD

Background： This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

Function：catalytic activity:Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.,cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 1 thiamine pyrophosphate per subunit.,disease:Has been implicated in the latent genetic disease Wernicke-Korsakoff syndrome (WKS) [MIM:277730]. WKS causes specific brain damage.,online information:Transketolase entry,similarity:Belongs to the transketolase family.,subunit:Homodimer.,

Subcellular Location：nucleus,nucleoplasm,peroxisome,cytosol,vesicle,myelin sheath,extracellular exosome,

Expression： Brain,Epithelium,Human uterus,Kidney,Liver,Lymph,Platelet,Thymus,