Target：TIS11D

Fields：Cellular senescence

Gene Name：ZFP36L2

Protein Name：Zinc finger protein 36 C3H1 type-like 2

Human Gene Id：678

Human Swiss Prot No：P47974

Mouse Swiss Prot No：P23949

Immunogen：The antiserum was produced against synthesized peptide derived from human TISD. AA range:207-256

Specificity：TIS11D Polyclonal Antibody detects endogenous levels of TIS11D protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ZFP36L2;BRF2;ERF2;RNF162C;TIS11D;Zinc finger protein 36; C3H1 type-like 2;ZFP36-like 2;Butyrate response factor 2;EGF-response factor 2;ERF-2;Protein TIS11D

Observed Band(KD)：55kD

Background： This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008],

Function：function:Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.,similarity:Contains 2 C3H1-type zinc fingers.,

Subcellular Location：Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. .

Expression：Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).