Target:Tip5
Gene Name:BAZ2A
Protein Name:Bromodomain adjacent to zinc finger domain protein 2A
Human Gene Id:605682
Human Swiss Prot No:Q9UIF9
Mouse Swiss Prot No:Q91YE5
Immunogen:The antiserum was produced against synthesized peptide derived from human BAZ2A. AA range:1281-1330
Specificity:Tip5 Polyclonal Antibody detects endogenous levels of Tip5 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:BAZ2A;KIAA0314;TIP5;Bromodomain adjacent to zinc finger domain protein 2A;Transcription termination factor I-interacting protein 5;TTF-I-interacting protein 5;Tip5;hWALp3
Observed Band(KD):210kD
Background:function:May play a role in transcriptional regulation interacting with ISWI. May serve a specific role in maintaining or altering the chromatin structure of the rDNA locus.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WAL family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 DDT domain.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 4 A.T hook DNA-binding domains.,subcellular location:Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.,subunit:Together with SMARCA5, it forms a complex termed NoRC (nucleolar remodeling complex).,tissue specificity:Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.,
Function:function:May play a role in transcriptional regulation interacting with ISWI. May serve a specific role in maintaining or altering the chromatin structure of the rDNA locus.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WAL family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 DDT domain.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 4 A.T hook DNA-binding domains.,subcellular location:Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.,subunit:Together with SMARCA5, it forms a complex termed NoRC (nucleolar remodeling complex).,tissue specificity:Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney
Subcellular Location:Nucleus, nucleolus . Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. .
Expression:Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.