Target：TIMP-4

Gene Name：TIMP4

Protein Name：TIMP-4

Human Gene Id：7079

Human Swiss Prot No：Q99727

Mouse Gene Id：110595

Mouse Swiss Prot No：Q9JHB3

Immunogen：Synthesized peptide derived from TIMP-4 at AA range: 174-223

Specificity：TIMP-4 Polyclonal Antibody detects endogenous levels of TIMP-4

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)

Observed Band(KD)：26kD

Background： This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008],

Function：function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,tissue specificity:Abundant in heart and present at low levels in many other tissues.,

Subcellular Location：Secreted.

Expression：Abundant in heart and present at low levels in many other tissues.