Target：RFIP5

Fields：Endocytosis

Gene Name：RAB11FIP5 GAF1 KIAA0857 RIP11

Protein Name：Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)

Human Gene Id：26056

Human Swiss Prot No：Q9BXF6

Mouse Swiss Prot No：Q8R361

Immunogen：Synthesized peptide derived from human protein . at AA range: 570-650

Specificity：RFIP5 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：71kD

Background：disease:Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE).,domain:Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+).,function:Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane.,PTM:Phosphorylated on serine and threonine residues.,similarity:Contains 1 C2 domain.,subunit:Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding.,tissue specificity:Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.,

Function：disease:Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE).,domain:Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+).,function:Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane.,PTM:Phosphorylated on serine and threonine residues.,similarity:Contains 1 C2 domain.,subunit:Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding.,tissue specificity:Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.,

Subcellular Location：Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Mitochondrion membrane; Peripheral membrane protein.

Expression：Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.