Target：RFA4

Fields：DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;Fanconi anemia pathway

Gene Name：RPA4

Protein Name：Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)

Human Gene Id：29935

Human Swiss Prot No：Q13156

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：RFA4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：28kD

Background： This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010],

Function：function:Absolutely required for simian virus 40 DNA replication in vitro. It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein.,subunit:Interacts with RPA1 and RPA3. In a tissue-specic manner, may replace RPA2 in the replication protein A heterotrimer.,tissue specificity:Preferentially expressed in placental and colon mucosa.,

Subcellular Location：Nucleus . Localizes to DNA repair foci after DNA damage.

Expression：Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.