Target：TP53INP1
Gene Name：TP53INP1
Protein Name：Tumor protein p53-inducible nuclear protein 1
Human Gene Id：94241
Human Swiss Prot No：Q96A56
Mouse Swiss Prot No：Q9QXE4
Immunogen：The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220
Specificity：TP53INP1 Polyclonal Antibody detects endogenous levels of TP53INP1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TP53INP1;P53DINP1;SIP;Tumor protein p53-inducible nuclear protein 1;Stress-induced protein;p53-dependent damage-inducible nuclear protein 1;p53DINP1
Observed Band(KD)：27kD
Background：function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.,induction:By adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way. At lower levels by ultraviolet irradiation.,subcellular location:Concentrated in PML/POD/ND10 nuclear bodies.,subunit:Interacts with TP53 and HIPK2.,tissue specificity:Ubiquitously expressed.,
Function：function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.,induction:By adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way. At lower levels by ultraviolet irradiation.,subcellular location:Concentrated in PML/POD/ND10 nuclear bodies.,subunit:Interacts with TP53 and HIPK2.,tissue specificity:Ubiquitously expressed.,
Subcellular Location：Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Expression：Ubiquitously expressed.
