Target:TP1
Gene Name:TEP1
Protein Name:Telomerase protein component 1
Human Gene Id:7011
Human Swiss Prot No:Q99973
Mouse Swiss Prot No:P97499
Immunogen:The antiserum was produced against synthesized peptide derived from human TEP1. AA range:171-220
Specificity:TP1 Polyclonal Antibody detects endogenous levels of TP1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TEP1;TLP1;TP1;Telomerase protein component 1;Telomerase-associated protein 1;Telomerase protein 1;p240;p80 telomerase homolog
Molecular Weight(Da):290kD
Background: This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function:function:Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.,similarity:Contains 1 NACHT domain.,similarity:Contains 1 TROVE domain.,similarity:Contains 21 WD repeats.,similarity:Contains 4 TEP1 N-terminal repeats.,subunit:Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.,tissue
Subcellular Location:Nucleus . Chromosome, telomere.
Expression:Ubiquitous.