Target:TOB1
Fields:RNA degradation
Gene Name:TOB1
Protein Name:Protein Tob1
Human Gene Id:10140
Human Swiss Prot No:P50616
Mouse Swiss Prot No:Q61471
Rat Swiss Prot No:Q8R5K6
Immunogen:The antiserum was produced against synthesized peptide derived from human TOB1. AA range:130-179
Specificity:TOB1 Polyclonal Antibody detects endogenous levels of TOB1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TOB1;TOB;TROB1;Protein Tob1;Transducer of erbB-2 1
Observed Band(KD):40kD
Background: This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Function:function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,
Subcellular Location:Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .
Expression:Ubiquitous.