Target：TNR27

Fields：Cytokine-cytokine receptor interaction;NF-kappa B signaling pathway

Gene Name：EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080

Protein Name：Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)

Human Gene Id：60401

Human Swiss Prot No：Q9HAV5

Mouse Swiss Prot No：Q8BX35

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TNR27 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：32kD

Background： The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016],

Function：function:Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF3 and TRAF6.,

Subcellular Location：Membrane; Single-pass type III membrane protein.

Expression： Brain,Fetal kidney,