Target：TNF-IP 8L2

Gene Name：TNFAIP8L2

Protein Name：Tumor necrosis factor alpha-induced protein 8-like protein 2

Human Gene Id：79626

Human Swiss Prot No：Q6P589

Mouse Gene Id：69769

Mouse Swiss Prot No：Q9D8Y7

Rat Gene Id：310663

Rat Swiss Prot No：Q6AYJ8

Immunogen：The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60

Specificity：TNF-IP 8L2 Polyclonal Antibody detects endogenous levels of TNF-IP 8L2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFAIP8L2;Tumor necrosis factor alpha-induced protein 8-like protein 2;TIPE2;TNF alpha-induced protein 8-like protein 2;TNFAIP8-like protein 2;Inflammation factor protein 20

Observed Band(KD)：20kD

Background：domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,

Function：domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,

Subcellular Location：cytoplasm,

Expression： Lymph node,Pancreas,Small intestine,