Target：VEGF-B

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;PI3K-Akt signaling pathway;Focal adhesion;Relaxin signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Pathways in cancer

Gene Name：VEGFB

Protein Name：Vascular endothelial growth factor B

Human Gene Id：7423

Human Swiss Prot No：P49765

Mouse Gene Id：22340

Mouse Swiss Prot No：P49766

Rat Gene Id：89811

Rat Swiss Prot No：O35485

Immunogen：The antiserum was produced against synthesized peptide derived from human VEGFB. AA range:91-140

Specificity：VEGF-B Polyclonal Antibody detects endogenous levels of VEGF-B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：VEGFB;VRF;Vascular endothelial growth factor B;VEGF-B;VEGF-related factor;VRF

Observed Band(KD)：21kD

Background： This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011],

Function：alternative products:Additional isoforms seem to exist,function:Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.,PTM:VEGF-B186 is O-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.,subunit:Homodimer; disulfide-linked. Can also form heterodimer with VEGF.,tissue specificity:Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.,

Subcellular Location：Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Expression：Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.