Target：TSHR

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Thyroid hormone synthesis;Regulation of lipolysis in adipocytes;Autoimmune thyroid disease

Gene Name：TSHR LGR3

Protein Name：Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)

Human Gene Id：7253

Human Swiss Prot No：P16473

Mouse Swiss Prot No：P47750

Rat Swiss Prot No：P21463

Immunogen：Synthesized peptide derived from human protein . at AA range: 280-360

Specificity：TSHR Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：84kD

Background： The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

Function：alternative products:Additional isoforms seem to exist,disease:Autoantibodies directed against the TSH receptor are directly responsible for the pathogenesis and hyperthyroidism of Graves disease (GRD) [MIM:275000]. Antibody interaction with the TSH receptor results in an uncontrolled receptor stimulation.,disease:Defects in TSHR are a cause of hyperthyroidism [MIM:603372]. Various types are known: autosomal dominant non-autoimmune hyperthyroidism (ADNH); sporadic congenital hyperthyroidism (SCH); hyperthyroidism associated with autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplas

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .

Expression：Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690).