Target：VAMP-1/2/3

Fields：SNARE interactions in vesicular transport

Gene Name：VAMP1/VAMP2/VAMP3

Protein Name：Vesicle-associated membrane protein 1/2/3

Human Gene Id：6843/6844/9341

Human Swiss Prot No：P23763/P63027/Q15836

Mouse Gene Id：22317/22318/22319

Rat Gene Id：25624/24803/29528

Rat Swiss Prot No：Q63666/P63045/P63025

Immunogen：The antiserum was produced against synthesized peptide derived from human VAMP-1/2/3. AA range:21-70

Specificity：VAMP-1/2/3 Polyclonal Antibody detects endogenous levels of VAMP-1/2/3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：VAMP1;SYB1;Vesicle-associated membrane protein 1;VAMP-1;Synaptobrevin-1;VAMP2;SYB2;Vesicle-associated membrane protein 2;VAMP-2;Synaptobrevin-2;VAMP3;SYB3;Vesicle-associated membrane protein 3;VAMP-3;Cellubrevin;CEB;Synaptob

Observed Band(KD)：13kD

Background： Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],

Function：function:Involved in the targeting and/or fusion of transport vesicles to their target membrane.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subunit:Interacts with VAPA and VAPB.,tissue specificity:Nervous system, skeletal muscle and adipose tissue.,

Subcellular Location：[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 2]: Cytoplasmic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein .

Expression：Nervous system, skeletal muscle and adipose tissue.