Target：UTP14A

Fields：Ribosome biogenesis in eukaryotes

Gene Name：UTP14A

Protein Name：U3 small nucleolar RNA-associated protein 14 homolog A

Human Gene Id：10813

Human Swiss Prot No：Q9BVJ6

Mouse Gene Id：72554

Mouse Swiss Prot No：Q640M1

Immunogen：The antiserum was produced against synthesized peptide derived from human UTP14A. AA range:321-370

Specificity：UTP14A Polyclonal Antibody detects endogenous levels of UTP14A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UTP14A;SDCCAG16;U3 small nucleolar RNA-associated protein 14 homolog A;Antigen NY-CO-16;Serologically defined colon cancer antigen 16

Observed Band(KD)：85kD

Background： This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],

Function：function:May be required for ribosome biogenesis.,miscellaneous:The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UTP14 family.,tissue specificity:Ubiquitously expressed.,

Subcellular Location：Nucleus, nucleolus .

Expression：Ubiquitously expressed.