Target:USP48
Gene Name:USP48
Protein Name:Ubiquitin carboxyl-terminal hydrolase 48
Human Gene Id:84196
Human Swiss Prot No:Q86UV5
Mouse Gene Id:170707
Mouse Swiss Prot No:Q3V0C5
Rat Gene Id:362636
Rat Swiss Prot No:Q76LT8
Immunogen:The antiserum was produced against synthesized peptide derived from human USP48. AA range:631-680
Specificity:USP48 Polyclonal Antibody detects endogenous levels of USP48 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:USP48;USP31;Ubiquitin carboxyl-terminal hydrolase 48;Deubiquitinating enzyme 48;Ubiquitin thioesterase 48;Ubiquitin-specific-processing protease 48
Observed Band(KD):120kD
Background: This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function:catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:Was named USP31 by some authors (PubMed:15354349 and PubMed:17081983).,function:Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 3 DUSP domains.,subunit:Interacts with TRAF2 and RELA.,tissue specificity:Widely expressed.,
Subcellular Location:Cytoplasm . Nucleus .
Expression:Widely expressed.