Target：Trypsin-3

Fields：Neuroactive ligand-receptor interaction;Pancreatic secretion;Protein digestion and absorption;Influenza A

Gene Name：PRSS3

Protein Name：Trypsin-3

Human Gene Id：5646

Human Swiss Prot No：P35030

Immunogen：The antiserum was produced against synthesized peptide derived from human Trypsin-3. AA range:117-166

Specificity：Trypsin-3 Polyclonal Antibody detects endogenous levels of Trypsin-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PRSS3;PRSS4;TRY3;TRY4;Trypsin-3;Brain trypsinogen;Mesotrypsinogen;Serine protease 3;Serine protease 4;Trypsin III;Trypsin IV

Observed Band(KD)：32kD

Background： This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010],

Function：catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Pancreas and brain.,

Subcellular Location：Secreted .

Expression：Detected in pancreas and pancreatic fluid (at protein level) (PubMed:6698368). Expressed in pancreas and brain (PubMed:8294000). Detected in ileum (PubMed:12021776).