Target：UBA6

Fields：Ubiquitin mediated proteolysis

Gene Name：UBA6 MOP4 UBE1L2

Protein Name：Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)

Human Gene Id：55236

Human Swiss Prot No：A0AVT1

Mouse Swiss Prot No：Q8C7R4

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：UBA6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：115kD

Background： Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008],

Function：alternative products:Named isoforms=3,function:Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,tissue specificity:Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.,

Subcellular Location：cytoplasm,cytosol,integral component of membrane,

Expression：Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.