Target：ZAC1

Gene Name：PLAGL1

Protein Name：Zinc finger protein PLAGL1

Human Gene Id：5325

Human Swiss Prot No：Q9UM63

Immunogen：The antiserum was produced against synthesized peptide derived from human PLAGL1. AA range:311-360

Specificity：ZAC1 Polyclonal Antibody detects endogenous levels of ZAC1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PLAGL1;LOT1;ZAC;Zinc finger protein PLAGL1;Lost on transformation 1;LOT-1;Pleiomorphic adenoma-like protein 1;Tumor supressor ZAC

Observed Band(KD)：50kD

Background： This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015],

Function：function:Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 7 C2H2-type zinc fingers.,

Subcellular Location：Nucleus .

Expression： Colon,Fetal kidney,Lung,Mammary gland,Pituitary,Placenta,