Target：TRP2

Fields：Tyrosine metabolism;Metabolic pathways;Melanogenesis

Gene Name：DCT

Protein Name：L-dopachrome tautomerase

Human Gene Id：1638

Human Swiss Prot No：P40126

Mouse Gene Id：13190

Mouse Swiss Prot No：P29812

Immunogen：The antiserum was produced against synthesized peptide derived from human DCT. AA range:51-100

Specificity：TRP2 Polyclonal Antibody detects endogenous levels of TRP2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DCT;TYRP2;L-dopachrome tautomerase;DCT;DT;L-dopachrome Delta-isomerase;Tyrosinase-related protein 2;TRP-2;TRP2

Observed Band(KD)：60kD

Background：catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

Function：catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

Subcellular Location：Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .

Expression： Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,