Target：REP-2

Gene Name：CHML

Protein Name：Rab proteins geranylgeranyltransferase component A 2

Human Gene Id：1122

Human Swiss Prot No：P26374

Mouse Swiss Prot No：Q9QZD5

Immunogen：The antiserum was produced against synthesized peptide derived from human CHML. AA range:128-177

Specificity：REP-2 Polyclonal Antibody detects endogenous levels of REP-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHML;REP2;Rab proteins geranylgeranyltransferase component A 2;Choroideraemia-like protein;Rab escort protein 2;REP-2

Observed Band(KD)：85kD

Background： The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008],

Function：function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family.,miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.,similarity:Belongs to the Rab GDI family.,subunit:Monomer. Interacts with Rab and Rab GGTase.,

Subcellular Location：Cytoplasm, cytosol .

Expression： Brain,