Target：TROP-2

Gene Name：TACSTD2

Protein Name：Tumor-associated calcium signal transducer 2

Human Gene Id：4070

Human Swiss Prot No：P09758

Mouse Gene Id：56753

Mouse Swiss Prot No：Q8BGV3

Rat Gene Id：494343

Rat Swiss Prot No：Q6P9Z6

Immunogen：The antiserum was produced against synthesized peptide derived from human TACD2. AA range:131-180

Specificity：TROP-2 Polyclonal Antibody detects endogenous levels of TROP-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TACSTD2;GA733-1;M1S1;TROP2;Tumor-associated calcium signal transducer 2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1

Observed Band(KD)：35kD

Background： This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009],

Function：disease:Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment.,function:GA733 tumor-associated antigen gene family may function as growth factor receptors.,PTM:The N-terminus is blocked.,similarity:Contains 1 thyroglobulin type-1 domain.,tissue specificity:Placenta, pancreatic carcinoma cell lines.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression：Placenta, pancreatic carcinoma cell lines.