Target：TRML2

Gene Name：TREML2 C6orf76 TLT2 UNQ6268/PRO20473

Protein Name：Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)

Human Gene Id：79865

Human Swiss Prot No：Q5T2D2

Mouse Swiss Prot No：Q2LA85

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：TRML2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：35kD

Background： TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008],

Function：function:Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counterreceptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.,induction:Induced in CD4 T-cells by concanavalin A.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with CD276 and this interaction enhances T-cell activation.,tissue specificity:Detected in cultured B cells, T cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.