Target：TRIB2
Gene Name：TRIB2 TRB2
Protein Name：Tribbles homolog 2 (TRB-2)
Human Gene Id：28951
Human Swiss Prot No：Q92519
Mouse Swiss Prot No：Q8K4K3
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：TRIB2 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：37kD
Background： This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009],
Function：function:Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.,miscellaneous:Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:May associate with the cytoskeleton.,tissue specificity:Highly expressed in peripheral blood leukocytes.,
Subcellular Location：Cytoplasm . Cytoplasm, cytoskeleton . May associate with the cytoskeleton. .
Expression：Highly expressed in peripheral blood leukocytes.
