Target：TRI23

Gene Name：TRIM23 ARD1 ARFD1 RNF46

Protein Name：E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23)

Human Gene Id：373

Human Swiss Prot No：P36406

Mouse Swiss Prot No：Q8BGX0

Rat Swiss Prot No：P36407

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TRI23 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：63kD

Background： The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008],

Function：function:Not known, the C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:In the C-terminal section; belongs to the small GTPase superfamily. Arf family.,subcellular location:Membrane-associated with the Golgi complex and lysosomal structures.,subunit:Interacts with PSCD1.,

Subcellular Location：Cytoplasm . Endomembrane system . Golgi apparatus membrane . Lysosome membrane . Membrane-associated with the Golgi complex and lysosomal structures.

Expression： Brain,