Target:ZIS
Gene Name:ZRANB2
Protein Name:Zinc finger Ran-binding domain-containing protein 2
Human Gene Id:9406
Human Swiss Prot No:O95218
Mouse Gene Id:53861
Mouse Swiss Prot No:Q9R020
Rat Gene Id:58821
Rat Swiss Prot No:O35986
Immunogen:The antiserum was produced against synthesized peptide derived from human ZNF265. AA range:106-155
Specificity:ZIS Polyclonal Antibody detects endogenous levels of ZIS protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:ZRANB2;ZIS;ZNF265;Zinc finger Ran-binding domain-containing protein 2;Zinc finger protein 265;Zinc finger; splicing
Observed Band(KD):34kD
Background:domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,
Function:domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,
Subcellular Location:Nucleus .
Expression: Brain,Epithelium,Fetal brain,Fetal kidney,Liver,Skin,Testis,Uterus,