Target：Zic1/2/3/4/5

Gene Name：ZIC1

Protein Name：Zinc finger protein ZIC 1

Human Gene Id：7545/7546/7547/84107/85416

Human Swiss Prot No：Q15915/O95409/O60481/Q8N9L1/Q96T25

Mouse Gene Id：22771/22773/22774

Immunogen：The antiserum was produced against synthesized peptide derived from human ZIC1/2/3/4/5. AA range:281-330

Specificity：Zic1/2/3/4/5 Polyclonal Antibody detects endogenous levels of Zic1/2/3/4/5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ZIC1;ZIC;ZNF201;Zinc finger protein ZIC 1;Zinc finger protein 201;Zinc finger protein of the cerebellum 1;ZIC2;Zinc finger protein ZIC 2;Zinc finger protein of the cerebellum 2;ZIC3;ZNF203;Zinc finger protein ZIC 3;Zinc finger p

Molecular Weight(Da)：55kD

Background： This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008],

Function：function:May play a role in cerebellar development.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.,

Subcellular Location：Nucleus. Cytoplasm . Localizes in the cytoplasm in presence of MDFIC overexpression. .

Expression：CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.